Sedating the ventilated patient

Typically, levels are (i) agitation, (ii) calm, (iii) responsive to voice alone, (iv) responsive to tactile stimulation, (v) responsive to painful stimulation only, and (vi) unresponsive to painful stimulation.

However, the association of early oversedation with clinical outcomes has not been thoroughly evaluated.

The aim of this study was to assess the association of early sedation strategies with outcomes of critically ill adult patients under mechanical ventilation (MV).

Examples of drugs which can be used for sedation include propofol, etomidate, ketamine, fentanyl, lorazepam and midazolam.

Sedation is typically used in minor surgical procedures such as endoscopy, vasectomy, or dentistry and for reconstructive surgery, some cosmetic surgeries, removal of wisdom teeth, or for high-anxiety patients.

The aim of this study is thus to describe the association of early sedation strategies (sedation depth and sedative choice) with clinical outcomes of mechanically ventilated adult ICU patients, with hospital mortality as the primary outcome.

This study was a secondary analysis of a multicenter prospective cohort conducted in 45 Brazilian ICUs (from the Brazilian Research in Intensive Care Network) from 12 states between 1 June 2011 and 31 July 2011 [ presents the participating ICUs in more detail.In order to use Medscape, your browser must be set to accept cookies delivered by the Medscape site.Medscape uses cookies to customize the site based on the information we collect at registration.Posted: June 2014Revised: August 2016, September 2016Authors: H. Sedation overuse is frequent and possibly associated with poor outcomes in the intensive care unit (ICU) patients.It therefore appears worthwhile for ICUs to review their practice and, if necessary, to consider implementing sedation scales and sedation guidelines.