Typically, levels are (i) agitation, (ii) calm, (iii) responsive to voice alone, (iv) responsive to tactile stimulation, (v) responsive to painful stimulation only, and (vi) unresponsive to painful stimulation.
However, the association of early oversedation with clinical outcomes has not been thoroughly evaluated.
The aim of this study was to assess the association of early sedation strategies with outcomes of critically ill adult patients under mechanical ventilation (MV).
Examples of drugs which can be used for sedation include propofol, etomidate, ketamine, fentanyl, lorazepam and midazolam.
Sedation is typically used in minor surgical procedures such as endoscopy, vasectomy, or dentistry and for reconstructive surgery, some cosmetic surgeries, removal of wisdom teeth, or for high-anxiety patients.
The aim of this study is thus to describe the association of early sedation strategies (sedation depth and sedative choice) with clinical outcomes of mechanically ventilated adult ICU patients, with hospital mortality as the primary outcome.